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ea0052oc2 | (1) | UKINETS2017

Systematic evaluation of the immune microenvironment of neuroendocrine tumours

Vesely Clare , Childs Alexa , Wong Yien Ning Sophia , Ogunbiyi Olagunju , Gander Amir , Luong Tu Vinh , Thirlwell Chrissie , Caplin Martyn , Peggs Karl , Marafioti Teresa , Quezada Sergio A. , Meyer Tim

Background: Immunotherapy is currently being explored in many tumour types with encouraging results, but has not yet been evaluated in neuroendocrine tumours (NET). Our aim is to characterise the immune landscape of NET and determine which immune-modulatory pathways control the tumour infiltrating lymphocytes (TILs) in order to develop a rational approach for immunotherapy in this tumour type.Methods: Peripheral blood and fresh tissue was obtained from c...

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ea0052p20 | (1) | UKINETS2017

Prophylactic right hemicolectomy in Appendiceal Neuroendocrine Neoplasms: challenging the current indications

Galanopoulos Michail , McFadyen Rory , Evans Nick , Naik Rishi , Drami Ioanna , Varcada Massimo , Ogunbiyi Olagunju , Luong Tu Vinh , Watkins Jennifer , Clark Ian , Laskaratos Faidon , Mandair Dalvinder , Caplin Martyn , Toumpanakis Christos

Introduction: To prevent loco-regional recurrence and subsequent development of distant metastases in Appendiceal Neuro-Endocrine Neoplasms (ANEN), the existing Guidelines have suggested several criteria for a prophylactic right hemicolectomy, following the initial appendectomy. However, some of those criteria seem rather arbitrary and have not been validated by large studies.Aim: To assess the outcomes of prophylactic right hemicolectomy (RHC), focusing...

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Endocrine Abstracts

Systematic evaluation of the immune microenvironment of neuroendocrine tumours

Prophylactic right hemicolectomy in Appendiceal Neuroendocrine Neoplasms: challenging the current indications

BiosciAbstracts